Once upon a time, the founder of alchemy led people from a dying world to a new land. In this fertile and harmonious land where man-made "Gods of Creation" act as guardians, humans lead a peaceful existence. However, a long time has since passed, and the "Dust" of death began to engulf Arcaus. Gods gone mad become heinous "Gods of Misfortune" and begin to devour the world, and ash demons born of dust bare their fangs at the living. Like burnt pieces of paper and worm-eaten clothes, the world finds itself in an era where the earth was being eroded by the ashes. The people were not entirely unprepared, however. Alchemists who wished to carry on the miracles brought upon by its founder gathered at the Cagliostro Academy, a school boasting the highest levels of wisdom. Among them is another—a young alchemist who knocks on the doors of the academy with aspirations in mind.